Let $F:\mathcal C\to \mathcal D$ be a functor. Then we get an induced map on the classifying spaces $BF:B\mathcal C\to B\mathcal D$. A famous theorem by Quillen says that, under mild assumptions, the homotopy fiber of $BF$ can be realized as the classifying space $B(Y\setminus F)$ of the comma category $Y\setminus F$ where $Y\in \mathcal D$.
Can the homotopy cofiber, i.e. the mapping cone, of $BF$ also be realized as a classifying space of some category? Does the classifying space of the other comma category give something interesting?
I am not sure about the result for categories but there are results on the case of the mapping cone $C(Bf)$ of $Bf: BG \to BH $ where $f: G \to H$ is a morphism of groups. These results are covered in Chapter 5 of the book partially titled Nonabelian Algebraic Topology (EMS Tracts, vol 15, 2011) (pdf available). Here the homotopy $2$-type of $C(Bf)$ is completely described by an "induced" crossed module $$\partial: f_*(G) \to H.$$ This result is one consequence of a 2-dimensional Seifert-van Kampen type theorem, for crossed modules. If $G,H$ are finite so also is $f_*(G)$, and various calculations are given.
More generally, the crossed module $$\partial: \pi_2(X \cup_g CA,X,x) \to \pi_1(X,x) $$ is analogously described in the case $A$ is connected and $g: (A,a) \to (X,x)$.
It is however unclear how to formulate an analogous result for monoids, let alone categories.