Observables are self-adjoint elements of a $C^*$algebra. As such, this structure seems sufficient to describe physics.
A theorem by Gelfand and Naimark says that a $C^*$algebra can always be faithfully represented as bounded operators on a Hilbert space, $B(H)$. Then one can introduces different topologies, and one can see von Neumann algebra as a $C^*$subalgebra of $B(H)$ that is moreover complete in one of those topologies.
In another question of Physics stack exchange https://physics.stackexchange.com/q/2043/2451 someone also talks about the Borel functional calculus, and one also compare von Neumann algebra to "non commutative" measure theory vs "non commutative" for $C^*$algebras.
My question is, is the introduction of von Neumann algebra only a technical thing or has it physical consequences? Or maybe more precisely, why is it important to consider several topologies on our algebra of operators?
ps: I posted the exact same question in physics, but it may be more relevant in math.
One consequence of being complete under various topologies, is that one can approximate an element of the von Neumann algebra by converging sequences from a dense subsets. But I guess that the more topologies such that our vN algebra is complete, the more possible dense subsets we have.