I am sincerely struggling with where to begin with either of these?
If am am asked to prove that (1) and (2) are inconsistent am I required to prove this formally by contradiction.
Looking at (1) would P & R become my 1st premise?
Perhaps if someone could please just explain what I need to do here or provide an example of how to go about proving this formally by contradiction I will take it from there.
Many thanks for taking time to assist me here!

Your premises are (1) $P\land R$ and (2) $R \to \lnot P$.
Elimination of $\land$ on (1) gives :
Elimination of $\to$ on (3) and (2) gives :
Elimination of $\to$ on (4) and (5) gives :
It should be clearer if you can draw an proof tree.