It is a well known fact that for two distinct primes $p$ and $q$, and natural numbers $m, n \geq 1$, there can be no simple group of order $p^nq^m$. Most proofs I have seen of this statement either make heavy use of the Sylow theorems, or just treat it as a corollary to Burnside's Theorem, the proof of which is even more involved. I have, however, not seen the following proof; I suspect that this is because it contains an error which I am unable to find.
Let $G$ be a group of order $p^nq^m$, with $p, q, m$ and $n$ as above. Then, by the first Sylow theorem, there exist two Sylow subgroups $P$ and $Q$ such that $|P| = p^n$ and $|Q| = q^m$. We will now show that the intersection of these groups is trivial. From Lagrange's theorem we immediately get $$ |P| = (P:P \cap Q)|P\cap Q| = p^n\\ |Q| = (Q:P \cap Q)|P\cap Q| = q^m $$ So that $|P\cap Q|$ must divide both $p^n$ and $q^m$. But this means that $|P\cap Q| = 1$, and therefore, that $P\cap Q$ contains only the identity. Again applying Lagrange's theorem, we get that there is a one-to-one correspondence between the cosets of $P$ and the elements of $Q$ (and vice versa). But this means that every element of $G$ can be written as a product of elements of $P$ and $Q$, which means that $G = PQ$, which in turn means that at least one of $P$ and $Q$ must be normal, and hence that $G$ cannot be simple.
The final argument that $G$ must be at least a semidirect product of $P$ and $Q$ seems somewhat flimsy to me, but I do not have enough experience in algebra to know where to poke the relevant holes into it. Any help taking this apart would be greatly appreciated.
Everything is correct up to $G = PQ$, but it does not follow that one of $P$ or $Q$ must be normal. In fact, there are examples where neither $P$ nor $Q$ is normal, but there is some other normal subgroup. For example, if $G = S_4$ with order $24 = 2^3 \cdot 3$, then neither a 2-Sylow subgroup (of order 8) nor a 3-Sylow subgroup (of order 3) is normal, but there is a normal subgroup of order 4.