How to prove that points $P_1(x_1,y_1,z_1)$, $P_2(x_2,y_2,z_2)$, $P_3(x_3,y_3,z_3)$, $P_4(x_4,y_4,z_4)$ are not coplanar if and only if the determinant $$\left|\begin{array}{cccc} x_1 & y_1 & z_1 & 1 \\ x_2 & y_2 & z_2 & 1 \\ x_3 & y_3 & z_3 & 1 \\ x_4 & y_4 & z_4 &1 \\ \end{array} \right| \neq 0$$
Not coplanar points in $\mathbb{R}^3$ if and only if its determinant is nonzero
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Claim:
The absolute value of this determinant
$$\left|\begin{array}{cccc} x_1 & y_1 & z_1 & 1 \\ x_2 & y_2 & z_2 & 1 \\ x_3 & y_3 & z_3 & 1 \\ x_4 & y_4 & z_4 &1 \\ \end{array} \right| $$
is the volume of a (skew) parallelepiped with vertices $(x_1,y_1,z_1),(x_2,y_2,z_2),(x_3,y_3,z_3),(x_4,y_4,z_4)$.
Proof: We know that the volume is the absolute value of the determinat that has as columns the vectors that represents the sides of the parallelepiped: $$ d= \left|\begin{array}{cccc} x_1-x_4 & y_1-y_4 & z_1-z_4 \\ x_2-x_4 & y_2-y_4 & z_2-z_4 \\ x_3-x_4 & y_3-y_4 & z_3-z_4\\ \end{array} \right| $$ Now, by co-factor decomposition of a determinant we have: $$ d= \left|\begin{array}{cccc} x_1-x_4 & y_1-y_4 & z_1-z_4&1 \\ x_2-x_4 & y_2-y_4 & z_2-z_4&1 \\ x_3-x_4 & y_3-y_4 & z_3-z_4&1\\ 0&0&0&1 \end{array} \right| $$ and, multiply the last columns bi $x_4$ and adding to the frst column we find $$ d= \left|\begin{array}{cccc} x_1 & y_1-y_4 & z_1-z_4&1 \\ x_2 & y_2-y_4 & z_2-z_4&1 \\ x_3 & y_3-y_4 & z_3-z_4&1\\ x_4&0&0&1 \end{array} \right| $$ Doing the same,i.e. multiplying by $y_4$ and $z_4$ and adding to the second and third columns we arrive at: $$ d= \left|\begin{array}{cccc} x_1 & y_1 & z_1&1 \\ x_2 & y_2 & z_2&1 \\ x_3 & y_3 & z_3&1\\ x_4&y_4&z_4&1 \end{array} \right| $$
That prove the claim.
Now the answer is obvious since the volume is null iff the four points are coplanar.
If the points are coplanar, then you can find the equation of a plane $P \equiv ax+by+cz+d=0$ such that your points all verify the equation with $(a,b,c,d) \neq (0,0,0,0)$. Hence the system $$\begin{cases} x_1 a + y_1 b + z_1 c + 1 d = 0 \\ x_2 a + y_2 b + z_2 c + 1 d = 0 \\ x_3 a + y_3 b + z_3 c + 1 d = 0 \\ x_4 a + y_4 b + z_4 c + 1 d = 0 \end{cases}$$ has a non trivial solution and the determinant vanishes (if not $(0,0,0,0)$ would be the only solution).
Conversely, if the determinant vanishes, the system has at least a non zero solution $(a,b,c,d)$ and this forms the equation of a plane satisfied by the points which are coplanar.