I would like to numerically solve a system of PDEs of the form
$$\mathbf{A}\dot{\mathbf{U}} + \mathbf{B}\mathbf{U}^{'} + F(\mathbf{U}) = 0$$
Where, $\dot{\mathbf{U}}(s, t)$ represents the time derivative, $\mathbf{U}^{'}(s, t)$ represents the space derivative, $\mathbf{U}$ is the vector of unknowns, and $F(\mathbf{U})$ is a nonlinear function of $\mathbf{U}$.
Both $\mathbf{A}$, and $\mathbf{B}$ are constant singular matrices.
So, the given system is a coupled system of PDEs and ODEs.
How to numerically solve such system of PDEs given initial and boundary conditions?. Which numerical method will be suitable?
Have you looked at the Keller Box scheme? It's described in this paper http://dx.doi.org/10.1016/j.amc.2009.07.054. It's relatively straight forward in principle and suitable for PDE's and non-linear systems. Depending on the size of your system though it can be a bit of a hassle to work out.
I'm not sure what your problem is but I've used it for solving one dimensional Stefan problems, where I have time and space derivatives and non-linear terms. It essentially applies the finite difference operators defined in the paper (pg 1614) and then you can linearise the problem using Newton's method.