By the Lander-Parkin conjecture, it is assumed there are no non-trivial integer solutions to either, $$a^8+b^8+c^8 = d^8+e^8+f^8\tag1$$ $$a^8+b^8 = c^8+d^8\tag2$$
However, if we relax $(1)$ a bit, $$1118^8 + 1937^8 + 2502045^4 = 455^8 + 1846^8 + 3200691^4\tag{3a}$$ then remove the common factor $13^8$ (pointed out by Adam Bailey), $$86^8 + 149^8 + 14805^4 = 35^8 + 142^8 + 18939^4\tag{3b}$$
In fact, there are infinitely many other primitive solutions like it by solving,
$$(a+b)^8+(a−b)^8+(4ab)^4=(c+d)^8+(c−d)^8+(4cd)^4$$
Question: Likewise, if we relax $(2)$ to either,
$$a^8+b^4 = c^8+d^4\tag4$$ $$a^8+b^4 = c^4+d^4\tag5$$
then are there non-trivial solutions to $(4)$ and $(5)$?
P.S. In response to Bailey's answer below, I forgot to add that solutions must be primitive. Otherwise, $(5)$ is easily solved.
Extending on On the eighth powers $A^8+B^8=C^8+D^8$: You provided a link to Wroblewski's database
Running a Python script$^1$ against that text file, I get:
So 8 out of 1420 primitive 4-tuples are of kind $(5)$, and there are none of kind $(4)$.
In case it is useful, here are formulae that generate infinite families of such 4-tuples. See also Finding formula that solves $w^4+x^4=y^4+z^4$ over the integers:
$$\begin{align} f_1(a) &= a^{7} + a^{5} - 2 a^{3} + 3 a^{2} + a \\ f_2(a) &= a^{13} - a^{12} - a^{11} - 5 a^{10} - 6 a^{9} + 12 a^{8} + 4 a^{7} - 7 a^{6} + 3 a^{5} + 3 a^{4} - 4 a^{3} - 2 a^{2} + a - 1 \\ f_5(a) &= a^{13} + 27 a^{12} - 214 a^{11} - 186 a^{10} - 2481 a^{9} + 861 a^{8} - 2804 a^{7} - 972 a^{6} - 2481 a^{5} - 27 a^{4} - 214 a^{3} + 294 a^{2} + a + 3 \end{align}$$
Then the 4-tuples are $(^h\!f(a,b), {}^h\!f(b,-a), {}^h\!f(a,-b),{}^h\!f(b,a))$ where $^h\!f$ denotes the homogenized version of eiter function.
Feed in $(a,b)=1$ and notice that the resulting 4-tuple might have a common factor of 2 (found empirically).
$^1$For reference, here is the script so you can play around with it: