It seems to me that if $U\subseteq\mathbb S^n$ is open, simply connected and proper, there must exist some point $x\in U$ such that $-x\notin U$. Otherwise, $U=-U$, and $U$ would satisfy the conditions of the title. Could such a subset exist?
2026-04-02 06:46:44.1775112404
Open + simply connected + antipodal + proper set in the sphere
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$\Bbb S^n$ minus its two poles is a proper, open, antipodal subset of $\Bbb S^n$. As it is homeomorphic to $\Bbb R^n$ minus a point, it is also simply connected as soon as $n\ge 3$.
I suppose, you do not want that all $\Bbb S^1\to U$ can be contracted to a point but rather all $\Bbb S^{n-1}\to U$?