For understanding of the question let's start with two examples:
We can factor $V(a,b,c)=a^4 + 2 a^2 b + b^2 - 2 a^2 c - 2 b c + c^2$ as a square, i.e we can write $V$ as square of a function $p(a,b,c)=a^2 + b - c$ so that holds $V=p^2$. Another example is $W(a,b)=a^2 + 2 a b + 2 a^{3/2} b + b^2 + 2b^2 \sqrt a + a b^2$ that can be factored as $W=r^2$ with $r(a,b)=a + b\sqrt a + b$.
The problem:
The function of interest is $U(a,b,c,d,e,f)=(d (a + e) + b (c + e) + (a + c) f)^2 - 4 (a c + a e + c e) (b d + b f + d f)$
with $(a,b,c,d,e,f)\in \mathbb{R}$. The aim is to take the square root of $U$. Therefore I tried to factor $U$ as a square, but failed, i.e. could not find the function $q(a,b,c,d,e,f)\in \mathbb C$ with $U=q^2$. How to prove that factorization is (not) possible? For factorization I consider for $q$ any mathematical function.
Considering it as a polynomial $P(a)$ in $a$ with coefficients parameterized in $b,c$, the condition for a multiple root is for $\gcd(P(a), P'(a))$ to have degree $\ge 1$. Calculating the polynomial $\gcd$ gives (verified by WA):
$$ \gcd(a^4 + 2 a^2 b + b^2 - 2 a^2 c - 2 b c + c^2, 4 a^3 + 4 a b - 4 a c) = a^2 + b - c $$
Therefore $(a^2 + b - c)^2 \,|\, P(a)$, and in fact $(a^2 + b - c)^2 \,=\, P(a)\,$ by degree considerations.
Considering it as a polynomial $Q(a)$ in $a$, it can be verified that $\gcd(Q(a), Q'(a)) = 1$ (WA) so $Q(a)$ has no polynomial factor at a power greater than $1$, which implies that it is not the square of another polynomial.