Suppose $R$ is a ring and $M$ is a projective left $R$-module. Suppose also that $M$ is a generator, meaning that every left $R$-module is a quotient of some possibly infinite direct sum of copies of $M$. Is it true that the center of the ring of endomorphisms of $M$ is isomorphic to the center of $R$?
Or do we maybe need more hypotheses, like that $M$ is finitely generated?
(I would prefer conditions on $M$ that can be stated using just the structure of the category of left $R$-modules as an additive category. 'Projective' and 'generator' are conditions of this sort. 'Finitely generated' is not such a condition, as far as I can tell, since to state it we need to know which object in the category of modules is $R$.)
At this moment I can't say either way when $M$ is infinitely generated, but when $M$ is finitely generated, you have a progenerator. At that point, $R$ is Morita equivalent to $\mathrm{End}(M_R)$ and Morita equivalent rings indeed have isomorphic centers.
Also,"finitely generated" is usually considered a categorical property, if that helps ease your reservation. I think it is not necessary to know which object is $R$, since in some sense the generators of $\mathrm{Mod}_R$ are interchangeable, and they have a categorical description.
Big fan, by the way.