Regions of $4$-dimensional space

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I am confused with the imagining the regions of $4$-dimensional space. I know that this space defines $2^4=16$ regions. Consider half upper space ($8$ regions). so $(2,3,4,1)$ belongs to the first region ($R_1$) and $(-2,3,4,1)\in R_2$. what we can say about other regions? for example $(-2,3,-4,1)\in R_?$ I wonder if anyone can spot a way to explain this for me?