$$ I=\int \frac{x^9}{(x^2+4)^6}\mathrm{d}x $$ Yeah I know, I can substitute: $$t=x^2+4\text{ or }2\tan\theta$$ So that: $$I=\frac12\int\frac{(t-4)^4}{t^6}\mathrm{d}t\text{ or } I=2^{-2}\int\tan^9\theta\cos^{10}\theta\mathrm{d}\theta$$ Both of which are a long tedious way* to solve, is there any easier method?
Update: I am not asking among these two, I am asking any "substitution" except these two, which is shorter.
Edit: I am very sorry I missed the ^$6$ in question.
Use Binomial Theorem for first and then divide by $t^6$, then integrate term wise.
$\require{cancel}\cancel{\text{Use Reduction formula for second or integration by parts.}}$

Hint :
Rewrite the integrand as $$\frac{x^9}{x^2+4}=x^7-4x^5+16x^3+\frac{256x}{x^2+4}-64x.$$
Edit :
The OP was changed into $$ \int\frac{x^9}{(x^2+4)^6}\ dx. $$ Use $x=2\tan\theta\ \Rightarrow\ dx=2\sec^2\theta\ d\theta$. $$ \int\frac{x^9}{(x^2+4)^6}\ dx=\frac14\int\tan^9\theta\ \cos^{10}\theta\ d\theta=\frac14\int\sin^9\theta\cos\theta\ d\theta. $$ Now, set $t=\sin\theta\ \Rightarrow\ dt=\cos\theta\ d\theta$. $$ \int\frac{x^9}{(x^2+4)^6}\ dx=\frac14\int t^9 dt=\frac1{40}t^{10}+C, $$ where $\sin\theta=\dfrac x{\sqrt{x^2+4}}$. The answer is $\color{blue}{\text{D}}$.