To prove this, the only idea I had was to divide $x^4+x+1$ by all polynomials over $F_2$ and show that it cannot be evenly divided.
This seems tedious and I am sure there is a more elegant way to prove this. Can anyone give hints or guide me towards a proof?
Hint If a quartic polynomial factors over some field, then it has a linear factor and/or an irreducible quadratic factor. Over $F_2$ there are only two (strictly) linear polynomials and only one irreducible quadratic polynomial, namely $x^2 + x + 1$, and these facts together reduce the checking to just a few cases.