show the set of valid second-order $\emptyset$-sentences is not R-enumerable
this would have the empty symbol set i.e. $S = \emptyset$
so it would be sentences that are universally or existentially quantified but would have no relations, functions or constants.
this just seems like a consequence of the Incompleteness of Second Order Logic. would it be proven similarly as $S_{\infty}-$sentences is proven to be not R-enumerable?
If you already know that the valid second-order sentences over the signature $S_\infty$ are not enumerable, you only have to construct from a $S_\infty$-sentence $\varphi$ a $\emptyset$-sentence $\varphi'$ such that $\varphi$ is valid if and only if $\varphi'$ is valid.
You can do this by replacing all distinct function symbols in $\varphi$ by distinct function variables of the same arity and all distinct relation symbols by distinct relation variables of the same arity and universally quantifying them.
Now assume you could enumerate all valid $\emptyset$-sentences. Whenerver you list a formula of the form $\forall R_1\dots R_n\forall f_1\dots f_m\psi'$ write down $\psi$, this would enumerate all valid $S_\infty$-sentences. Contradiction.
The result for $S_\infty$ follows from Trakhtenbrot's theorem and the fact that finiteness is definable by a second-order sentence.