A teaching question. What is or might be simplest form for rational exponents? My search turns up little for the concept other than a translation of the simplest form for n-th root radicals. But that leads to ugly things such as...
$\large{5^\frac{7}{3}\rightarrow 5^2\centerdot 5^\frac{1}{3}}$
$\large{x^{-\frac{2}{3}}\rightarrow x^{-1}\centerdot x^\frac{1}{3}}$
...when the whole point of rational exponents is beauty and elegance.
"Lowest terms" for a rational is usually understood to mean $a/b$, with $a$ and $b$ integers, $b\gt 0$, and $\gcd(a,b)=1$. (That is, the "sign" goes with the numerator).
For $p/q$ written in lowest terms, the definition of $a^{p/q}$ is that $a^{p/q} = r$ where $r$ is the unique nonnegative real number such that $r^q = a^p$; that is, $\displaystyle a^{p/q} = \sqrt[q]{a^p}$. This includes the cases with $p\gt q$ and with $-p\gt q$. If you want only fractional exponents of the form $p/q$ with $0\lt p\lt q$, then of course this can be done fairly easily, but it does not seem to me to lead to much simplification for algebraic manipulations (though it may for actual computations).
Rational exponents in lowest terms with even denominator are only, a priori, defined for positive bases when working in the reals.