My try : Tried to solve by relation between coefficient and roots of n- degree equations but unable to proceed because of the variables. But just found the interesting thing that the signs of $a , b , c$ and $d$ are as same as in relation.
Answer : $a= 60, b= -160 ,c= 240 , d= -192$
Using Vieta's formula and AM-GM: $$x_1+x_2+x_3+x_4+x_5+x_6=12;\\ x_1x_2x_3x_4x_5x_6=64;\\ x_1+x_2+x_3+x_4+x_5+x_6\ge 6\sqrt[6]{x_1x_2x_3x_4x_5x_6} \Rightarrow x_1x_2x_3x_4x_5x_6 \le 64,$$ the equality occurs for $x_1=x_2=\cdots= x_6=2$. So, the equation is: $(x-2)^6=0.$
Expand and find the coefficients.