Let $M$ be a real symmetric positive-definite matrix and $D_a$ the diagonal matrix $$D_a = \left[\begin{array}{ccccc}a & & & &\\& 1 & & &\\& & 1 & &\\& & & \ddots &\\& & & & 1\end{array}\right].$$
If the eigenvectors and eigenvalues of $M$ are known, can anything be said about the spectrum of $D_a M$, without recomputing its spectral decomposition?
Generally speaking, $D_aM=D_aM^{1/2}M^{1/2}$ has same eigenvalues as $M^{1/2}D_aM^{1/2}$. Thus its signature is $(n,0,0)$ if $a>0$, $(n-1,1,0)$ if $a<0$ and $(n-1,0,1)$ if $a=0$.
Now we assume that $a-1$ is small. Let $\chi(x,a)$ be the charac. polynomial of $D_aM$ , $(\lambda_i)_i$ (resp$(\mu_i)_i)$ be the (positive) eigenvalues of $M$ (resp. $D_aM$). Note that $\chi(x,a)=\det(xI-M)+(a-1)\det(xI-M-xE_{1,1})$ where $E_{1,1}$ is the matrix, the entries of which are $0$ except one of index $(1,1)$ which is $1$. Above all, we assume that the eigenvalues of $M$ are simple (then the $(\mu_i)_i$ are real analytic functions of $a$). Then $\dfrac{dx}{da}=-\dfrac{\dfrac{\partial\chi}{\partial a}}{\dfrac{\partial\chi}{\partial x}}$ and let $\rho_i=\dfrac{dx}{da}_{a=1,x=\lambda_i}$ (note that $\dfrac{\partial\chi}{\partial a}$ is constant). Finally $\mu_i\approx \lambda_i+(a-1)\rho_i$.