In the following question:
Log concavity of binomial coefficients: $ \binom{n}{k}^2 \geq \binom{n}{k-1}\binom{n}{k+1} $
It is proven via a combinatorial injective argument.
However, by noticing that the set of identical pairs of choices cannot be in the output space of the transformed pair of selections, we can strengthen the inequality to
$$\binom{n}{k-1}\binom{n}{k+1} \leqslant \binom{n}{k}^2 - \binom{n}{k}$$
From which the natural question follows: Is there a combinatorial argument that allows us to remove the equality case?
(This has been checked numerically and holds)
That is, how can we extend the argument even further to prove
$$\binom{n}{k-1}\binom{n}{k+1} < \binom{n}{k}^2 - \binom{n}{k}$$
I will work in the context of the injection argument. Note that inequality only holds for when $n > k > 0$.
We see that the $\binom{[n]}{k-1} \binom{[n]}{k+1}$ sets correspond to the sets $(X, Y)$ in $\binom{[n]}{k}^2$ for which there exists some $i$ such that the number of elements up to $i$ in $X$ exceeds the number of elements up to $i$ in $Y$. We also see that the $\binom{n}{k}$ in your statement refers to the $(X, Y)$ in $\binom{[n]}{k}^2$ for which $X = Y$, so won't be mapped to by the injection.
But we also have the following: For some subset $A$ of $\{3, 4, 5, \dots, n\}$ of size $k-1$, consider the sets $X=\{2\} \cup X$ and $Y = \{1\} \cup X$. Then again $(X, Y)$ is not mapped to, so thus inequality cannot occur.