Consider a Riemannian manifold $(S,g)$ of dimension 2. What can we say about the possibility of an isometric immersion of this surface into $\mathbb{R}^3$?
Of course this is not unique, even up to rigid motions (like in the case of zero Gaussian curvature). How can we find at least one of the possible isometries? Do we have a condition for uniqueness?
If you want to make it simpler, think about a $U \subset \mathbb{R}^2$ with assigned $g_{ij}\neq \delta_{ij}$ (with respect to the standard Cartesian coordinates).
The Cartan-Janet Theorem says (see, for example, Spivak, A Comprehensive Introduction to Differential Geometry, Chapter 11 in volume V) that if you start with a real analytic metric, you can locally isometrically embed the surface in $\Bbb R^3$.
Of course, hoping for a global theorem is hoping too much, as you can't embed isometrically a torus with $g>1$ and constant negative curvature metric in $\Bbb R^3$. Indeed, you can't isometrically embed any compact surface with everywhere negative curvature.
REMARK: A bit of exploration with Google leads me to a new book by Han and Hong called Isometric Embedding of Riemannian Manifolds in Euclidean Spaces. They also discuss the history of the problem. They mention Pogorelov's 1972 example of a $C^{2,1}$ metric on the unit ball so that there's no $C^2$ isometric embedding of any neighborhood of the origin into $\Bbb R^3$.