Of course, since the cardinality of $\mathbb{R}$ exceeds the cardinality of $\mathbb{Q}$, there does not exist a bijection between $\mathbb{Q}^\ast$ and $\mathbb{R}^\ast$, let alone a group isomorphism.
My question is whether it is also possible to prove that these multiplicative groups are not isomorphic without using a cardinality argument.
In $\mathbb{R}^\ast$ every element has a cuberoot; that is, for any $a$ in $\mathbb{R}^\ast$ there is an element $b$ such that $b^3=a$. In $\mathbb{Q}^\ast$ there are elements that do not.