This is what I have so far, I am not really sure what I am doing is correct. Can anyone help with this?
Given $F(x,y)=x^3y^4-\ln (x^2y)+e^{3x-6y}$
Find $f_x,f_y,f_{xx},f_{xy},f_{yy}$
$$P_x=3x^2y^4-\frac{2xy}{xy}+e^{x-6y}$$ $$P_{xx}=6xy^4-2+e^{-6y}$$ $$P_y=x^34y^3-\frac{x^2}{x^2}+e^{3x-6}$$ $$P_x=x^312y^2-1+e^{3x}$$ $$P_{xy}=\frac{6xy^4-2+e^{-6y}}{x^3-12y^2-1+e^{3x}}$$
There is nothing to be worried about even when partially differentiating with respect to an independent variable.
NOTE: When you partially differentiate with respect to $x$, treat $y$ as constant.
I'll solve the first one for you as an example
$(x^3y^4)_x=3x^2y^4$
$(\ln(x^2y))_x={1\over x^2y}\cdot(x^2y)_x={2xy\over x^2y}$ (You missed the square in the denominator)
$(e^{3x-6y})_x=e^{3x-6y}\cdot (3x-6y)_x=3e^{3x-6y}$
Now club the three.