Let $X$ be a topological space and $A \subseteq X$. Then, let $X_A$ denote $X/R$, where:
$$R = \{ (x,y) : x = y \text{ or } (x,y) \in A \times A\}$$
i.e. we collapse $A$ to a point. I will call $X_A$ the quotient of $X$ by $A$.
Conjecture: Let $X = \mathbb{R}^n$ and $K \subseteq X$ be compact and path-connected with path-connected complement. Then, $X_K$ is homeomorphic to $X$.
You may note that, for the case $n=2$, this is similar to the Jordan curve theorem, which I don't want to assume.
I think that this is true, but it's quite difficult to construct the required homeomorphism; I think I would need to brush up my analysis first. Equally, if it's not true, I don't have the imagination to guess what the counterexample looks like. I've only proved a basic lemma:
Lemma: Let $Y,Z$ be topological spaces. Let $U_n \subseteq Y$ be an increasing family of open sets such that $\bigcup_n U_n = Y$ and for each $n$, there exists $f_n$ such that
- $f_n : U_n \to Z$ is a homeomorphism onto its image
- $f_n \restriction_{U_k}=f_k$ for any $k \le n$
- $\bigcup_n f_n(U_n) = Z$
Then, $Y \cong Z$.
Of course, this is nothing astonishing; the proof is just to take the union of all the homeomorphisms, so to speak. But it should simplify the proof of the conjecture.
Here is an answer clarifying and correcting my earlier comment.
For each $n\ge 3$, there exists a subset $A\subset R^n$ homeomorphic to $[0,1]$ (hence, path-connected with connected complement) such that $Q=R^n/A$ is not a topological manifold, hence, is not homeomorphic to $R^n$. The example is essentially due to Bing: Take a (wild) arc $A$ embedded in $R^n$ such that $R^n\setminus A$ is not simply-connected. Then $Q$ is simply-connected but removing a point from $Q$ (namely, the projection of $A$) makes it non-simply-connected. Hence, $Q$ cannot be a topological manifold.
Suppose that $A\subset R^2$ is a compact such that its complement is simply-connected (which follows from your assumptions but is strictly weaker). Then $R^2/A$ is homeomorphic to $R^3$.
This is an application of several nontrivial results which will also require several definitions.
(a) A compact metrizable space is said to be cell-like if for some (equivalently, every) embedding $i$ of $A$ in the Hilbert cube $H$ has the property that for every neighborhood $U$ of $i(A)$ in $H$, the inclusion $i(A)\to U$ is null-homotopic. For instance, a closed ball is cell-like but the circle is not.
This definition is a bit hard to digest. But there is a sufficient condition for $A$ to be cell-like:
(b) A compact subset $A\subset R^k$ is said to be cellular if there is a decreasing sequence of neighborhoods $U_j$ of $A$ in $R^k$ such that:
(i) Each $U_j$ is homeomorphic to $R^k$.
(ii) $\bigcap_{j} U_j=A$.
As it turns out, if $A\subset R^k$ is compact and $R^k\setminus A$ is homeomorphic to $R^k$, then $A$ is cellular. This theorem is due to M.Brown:
Brown, Morton, The monotone union of open $n$-cells is an open $n$-cell, Proc. Am. Math. Soc. 12, 812-814 (1961). ZBL0103.39305.
In particular, if $A\subset R^2$ is a compact with simply-connected complement, then $A$ is cellular.
Lastly, R.Moore proved in
Moore, R. L., Concerning upper semi-continuous collections of continua., Trans. Am. Math. Soc. 27, 416-428 (1925). ZBL51.0464.03.
that if $A\subset R^2$ is cell-like then $R^2/A$ is homeomorphic to $R^2$ (in fact, he proves much more but you do not need this).
See also
Edwards, Robert D., The topology of manifolds and cell-like maps, Proc. int. Congr. Math., Helsinki 1978, Vol. 1, 111-127 (1980). ZBL0428.57004.
for more details and references.