Trigonometry substitution issue with sign

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When solving an integral such as $\displaystyle\int\frac{dx}{\sqrt{x^2+4}}$, you eventually end up with

$$ \ln\lvert\sec\theta+\tan\theta\rvert+C.$$

The next step is to rewrite this in terms of $x$. My book does the following: $x=2\tan\theta$, so by drawing a triangle, it can be seen that $x$ is the opposite side, $2$ the adjacent one, and finally, $\sqrt{2^2+x^2}$ the hypotenuse. Therefore, $$\sec\theta=\frac{\sqrt{2^2+x^2}}2.$$ The problem that I see however is that $\sqrt{2^2+x^2}$ is the magnitude of the hypotenuse, so this has lost a possible negative sign since it is not necessarily true that

$$ \sec\theta = \frac{|r|}{2}.$$

How can this be omitted?

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When you make the substitution $x=2\tan \theta$, you have to be careful to specify the domain of $\theta$: the substitution is only valid if $\theta$ has a small enough domain for $\tan \theta$ to be continuous. The simplest possible choice of domain is probably $-\frac{\pi}{2} < \theta < \frac{\pi}{2}$. Note that the range of $2\tan \theta$ on this domain is the entire real line, so taking $\theta$ in this domain doesn't lose any generality.

But when $-\frac{\pi}{2} < \theta < \frac{\pi}{2}$, we always have $\sec \theta > 0$. So in fact, if you make this choice of domain, it is always true that $2 \sec \theta=\sqrt{x^2+4}$, without any sign issues.

It's instructive to think about what happens if you choose a different domain for $\theta$. If $\sec \theta > 0$ on that domain, nothing will change. If $\sec \theta < 0$ on that domain, then

$$\int \frac{dx}{\sqrt{x^2+4}}=\int \frac{\sec^2 \theta \,d\theta}{-\sec \theta}=-\int \sec \theta \,d\theta $$

because $\sqrt{x^2+4}$ is still positive. So the integral in terms of $\theta$ evaluates to $-\ln|\sec \theta +\tan \theta|+C$. Then, when we rewrite in terms of $x$, we again have $\sec \theta=-\sqrt{x^2+4}$, so the integral in terms of $x$ is

$$-\ln\left|-\sqrt{x^2+4}+x\right|+C=-\ln\left(\sqrt{x^2+4}-x\right) +C\, ,$$

because $\sqrt{x^2+4} > x$ for all $x$.

But then

\begin{align*} -\ln\left(\sqrt{x^2+4}-x\right)&=\ln\left(\frac{1}{\sqrt{x^2+4}-x}\right)\\ &=\ln\left(\frac{\sqrt{x^2+4}+x}{(\sqrt{x^2+4})^2-x^2}\right)&\text{(multiplying by the conjugate)}\\ &=\ln\frac{\sqrt{x^2+4}+x}{4}\\ &=\ln(\sqrt{x^2+4}+x)-\ln 4 \, . \end{align*}

So we get the nearly same result whatever domain we choose, but the constant term may be different.

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Is this perhaps a possible solution?

$$\int{\frac{dx}{+\sqrt{x^2+2^2}}}=\int{\frac{dx}{+2\sqrt{sec^2(\theta)}}}=\int{\frac{2sec^2(\theta)}{2\mid sec(\theta)\mid}}d\theta=\int{\mid{sec(\theta)}}\mid d\theta >0 $$

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Let's work through it from the beginning $$x=2\tan\theta, dx=2\sec^2\theta d\theta.\\ \int \frac{dx}{\sqrt{x^2+4}}=\int\frac{2\sec^2\theta d\theta}{\sqrt{4\tan^2\theta+4}}=\int\frac{2\sec^2\theta d\theta}{|2\sec \theta|}=\int|\sec\theta|d\theta=\int\sec\theta d\theta\\ =\ln(\tan\theta+\sec\theta)+C.$$

Where the modulus sign can be removed because we can assume $\theta\in(-\frac{\pi}{2},\frac{\pi}{2})$ to get all the values of $x$.

Again, when using $2\sec\theta=\pm\sqrt{x^2+4}$, we know that $\theta\in(-\frac{\pi}{2},\frac{\pi}{2})$, so the minus sign can be ignored.

If you try to use other ranges of $\theta$, the negative sign(if any) in the above steps should cancel out, and you can get the same result.