It is easily checked that $\displaystyle\sum_{i\ =\ 0}^{n}\left(\, -1\,\right)^{i} \binom{n}{i} = 0$, for example by appealing to the binomial theorem.
I'm trying to figure out what happens with the truncated sum
$\displaystyle\sum_{i\ =\ 0}^{D}\left(\, -1\,\right)^{i}\binom{n}{i}$.
How far away from $0$ can this get, as a function of $D$ ?.
I'm mostly interested in the case of when $D \ll n$, such as
$D \sim \,\sqrt{\,n\,}\,$.
Thanks !
Let $n\ge 2\in\mathbb N$ (since the case $n=1$ is trivial).
For $0\le D\lt n$, we can prove the following by induction: $$\sum_{i=0}^{D}(-1)^i\binom{n}{i}=(-1)^D\binom{n-1}{D}.$$
For $D=0$, it holds trivially.
For a $D$ such that $0\le D\le n-2$, suppose that it holds. Then, $$\begin{align}\sum_{i=0}^{D+1}(-1)^i\binom{n}{i}&=(-1)^{D+1}\binom{n}{D+1}+\sum_{i=0}^{D}(-1)^i\binom{n}{i}\\&=(-1)^{D+1}\binom{n}{D+1}+(-1)^D\binom{n-1}{D}\\&=(-1)^{D+1}\left\{\binom{n}{D+1}-\binom{n-1}{D}\right\}\\&=(-1)^{D+1}\binom{n-1}{D+1}\end{align}$$ Hence, it holds when $D+1$.
Therefore, it holds for any $0\le D\lt n$. Q.E.D.
From this, you'll also see how far away from $0$ it can get.