Let $H$ be a separable Hilbert space. Suppose that $\mathscr{A}$ and $\mathscr{B}$ are some unital $C^*$-algebras of operators acting on $H$, not necessary coinciding with $C^*$-algebra of all the possible operators acting on $H$. Suppose that they are $*$-isomorphic with the isomorphism $\mathfrak{n}:\mathscr{A}\to\mathscr{B}$.
What are the conditions for existing a unitary operator $\mathcal{U}:H\to H$, such that $\mathfrak{n}(\mathcal{A})=\mathcal{U}\mathcal{A}\mathcal{U}^{-1}$ for all $\mathcal{A}\in\mathscr{A}$?
Any conditions on the algebras $\mathscr{A}$ and $\mathscr{B}$, e.g. commutative algebras, UHF algebras, etc., when the statement can be true, are also welcome.
Indeed, we have
The forward direction is trivial, and the reverse direction follows from the fact that all automorphisms of $B(H)$ are inner.