Let $(S,\leq)$ be a countable linear order with the following property (H):
for all positive integers $n$, and all increasing sequences $s_1 < s_2 < \ldots < s_n$ and $t_1 < t_2 < \ldots < t_n$, there is an order automorphism $\alpha$ of $S$ such that $\alpha(s_i) = t_i$ for all $i = 1, 2, \ldots, n$.
Then by a result of Cantor, $(S,\leq)$ is order isomorphic to $(\mathbb{Q},\leq)$.
Now suppose that $S$ is not countable, but also having property (H). It seems to me that the order automorphism group of $(S,\leq)$ should share many properties with the order automorphism group of $(\mathbb{Q},\leq)$.
What are some of the important properties that they do not share ? What are the (main) differences ?
One difference is the number of orbits of increasing length-$\omega$ sequences. This isn't really a difference in the automorphism groups per se, but rather their actions, but I think it's interesting enough to note.
In $Q=(\mathbb{Q},<)$ there are exactly three kinds of increasing sequence (up to automorphism, in the sense that any two sequences of the same type can be swapped by an automorphism of $Q$). Namely, an increasing sequence $(a_i)_{i\in\omega}$ of rationals has exactly one of the following three properties, and if $(a_i)_{i\in\omega},(b_i)_{i\in\omega}$ have the same property then there is an automorphism $\alpha$ of $Q$ such that $\alpha(a_i)=b_i$ for all $i\in\omega$:
Unbounded: the set $\{a_i:i\in\omega\}$ has no upper bound.
Bounded but no least upper bound: the sequence is bounded but whenever $b\in Q$ is such that $b>a_i$ for all $i$ there is some $c\in Q$ such that $c>a_i$ for all $i$ and $c<b$.
Has a least upper bound: there is some $b\in Q$ such that $b>a_i$ for all $i$ and for all $c<b$ there is some $i$ such that $c<a_i$.
For example, taking $a_i=i$ yields a sequence of the first type, taking $a_i=\pi-{1\over i+1}$ yields a sequence of the second type (the "$+1$" addresses the case $i=0$), and taking $a_i=1-{1\over i+1}$ yields a sequence of the third type.
By contrast, this can fail for uncountable orders with property (H). For example, $R=(\mathbb{R},<)$ has property $(H)$ but only two types of increasing $\omega$-sequences (every bounded sequence has a least upper bound).