I am trying to get an upper bound for $$S_{n,r}=\sum_{i=0}^n \binom{n}{i} \left(\frac{\binom{n}{i}}{2^n}\right)^{r} .$$
Any hints would be greatly appreciated. I thought of using Stirling's approximation but I worried that doesn't give good bounds for binomial coefficients over the full range.
Actually, you can do a lot better than @Xoff, since $$\binom{n}{i} \leq 2^n/\sqrt{n}$$, so $$S_{n, r} \leq 2^n/n^{r/2}.$$