When neither one of premises and conclusion includes a number like "1", like the following, I could at least proceed to some extent (although I don't know how to connect Q(y) of the first premise and Q(x, y) of the second premise...)
Premises:
∀x∀y(P(x,y) ↔ Q(y))
∀x∀y(Q(x,y) ↔ R(x,y))
Conclusion:
∀x∀y(P(x,y) ↔ R(x,y))
1 ∀x∀y (P(x, y) ↔ Q(y)) Premiss
2 ∀x∀y (Q(x, y) ↔ R(y)) Premiss
3 ∀y (P(x, y) ↔ Q(y)) 1 (∀E)
4 (P(x, y) ↔ Q(y)) 3 (∀E)
5 ∀y (Q(x, y) ↔ R(y)) 2 (∀E)
6 (Q(x, y) ↔ R(y)) 5 (∀E)
7 (P(x, y) → Q(y)) 4 (↔E)
..... don't know how to keep going...
, but when formulas involve some concrete numbers like "1" shown below, I don't even know where to start from. What's the purpose of using a concrete number instead of general expression like x or y? And how do I work on this problem?
Premises:
∀x∀y(P(x,y)→Q(x,y))
∀x(Q(x,1) V R(1))
Conclusion:
∀xƎy(Q(x,y) V R(y))


We can use terms of the language, i.e. variables, constant and "complex" terms built up from "simpler" terms using function symbols.
Thus, we can use $1$ if it is part of the language.
In the example above, $1$ is used as a constant and it has no special meaning.
Thus, the subformula $R(1)$ simply means that the "object" referred to by $1$ has "property" $R$.
From premise : $∀x(Q(x,1) \lor R(1))$ we derive (using $(\forall \text E)$) :
and then we have to use $(\exists \text I)$ to get :