Consider the the PDE
$$A(x, y)\partial_{xx} u + B(x, y)\partial_{xy}u + C(x, y)\partial_{yy}u=h(x, y) $$
Now I want to make a variable substitution $\xi=f(x, y), \eta=g(x,y)$, so I can get $u$ as a function of $\xi$ and $\eta$. So
$$\partial_{x}u=\partial_{x}\xi\partial_{\xi}u + \partial_{x}\eta\partial_{\eta}u$$
Then $$\partial_{xx}u=\partial_{x}\left(\partial_{x}\xi\partial_{\xi}u + \partial_{x}\eta\partial_{\eta}u\right)\overset{?}{=}\partial_{xx}\xi\partial_{\xi}u + \partial_{x}\xi\partial_{x\xi}u + \partial_{xx}\eta\partial_{\eta}u + \partial_{x}\eta\partial_{x\eta}u$$
I am supposed to find terms like $\partial_{\xi\xi} u$, but how? The question-mark over the equality is that I am unsure if and how the chain rule should be applied.
The equality $\partial_{xx}u=\partial_{x}\left(\partial_{x}\xi\partial_{\xi}u + \partial_{x}\eta\partial_{\eta}u\right)\overset{?}{=}\partial_{xx}\xi\partial_{\xi}u + \partial_{x}\xi\partial_{x\xi}u + \partial_{xx}\eta\partial_{\eta}u + \partial_{x}\eta\partial_{x\eta}u$ is wrong, because $\partial_x\xi$ depends on $x$ and $\partial_\xi u$ too.
I suppose you need only linear change of variable (when $A,B,C$ are constant). In this case it's easier.
Let $f(x,y)=ax+by$ and $g(x,y)=cx+dy$. In this case $\partial_x \xi=a$ and $\partial_x \eta=c$, so:
$\partial_{x}u=\partial_{x}\xi\partial_{\xi}u + \partial_{x}\eta\partial_{\eta}u=a\partial_{\xi}u+c\partial_{\eta}u$
Then as you write:
$\partial_{xx}u=\partial_x(a\partial_{\xi}u+c\partial_{\eta}u)=a^2\partial_{\xi \xi} u+ 2ac\partial_{\xi \eta} u+ c^2\partial_{\eta \eta}u$
$\bf{Edit:}$You can apply chain rule again to $v=\partial_{\xi}u$, you get:
$\partial_{x}v=\partial_{x}\xi\partial_{\xi}v + \partial_{x}\eta\partial_{\eta}v=\partial_{x}\xi\partial_{\xi \xi}u + \partial_{x}\eta\partial_{\eta \xi}u$
The same with $\partial_{\eta x}u$