What are significant applications of the extended binomial coefficient?

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The binomial coefficient \begin{pmatrix} n\\k \end{pmatrix} is well understood when $n$ is a positive integer. According to Wikipedia, the definition can be extended by replacing $n$ by an arbitrary number α (negative, real, complex). My question is: what are some significant applications when α is

  1. negative
  2. rational
  3. real
  4. complex?