Consider a problem from Categories for the Working Mathematician:
For categories $A$, $B$, and $C$ establish natural isomorphisms
$$ (A \times B)^C \cong A^C \times B^C, \\ C^{A \times B} \cong (C^B)^A $$
I understand the notation $F_1 \cong F_2$ denotes "$F_1$ is naturally isomorphic to $F_2$" (for functors $F_1$ and $F_2$).
Question: What does this question then mean? Here the expressions on each side of $\cong$ denote categories, not functors. For example, $(A \times B)^C$ is a functor. So I don't know how to parse the meaning of this question. What is a natural isomorphism between categories?
You can think of these as functors with three inputs taken from the category of categories (with some components contravariant): e.g.
$(- \times -)^- :\underline{Cat} \times \underline{Cat} \times \underline{Cat}^{op} \rightarrow \underline{Cat}$
You can then apply what you know about natural isomorphisms between these functors. (Of course, the components of these natural isomorphisms are themselves functors, but it is important not to confuse them with the functors that you are finding isomorphisms between)