For example, I'm asked to find the line integral of $C_1$ above for a vector field $\vec F=x\vec i + y\vec j$
To do so I first try and find a parameterization of $C_1$. I parameterize $C_1$ as $\vec r(t)=t\vec i+(-2t+2)\vec j$.
But apparently this is already incorrect, as the correct parameterization was $\vec r(t) = (1-t)\vec i + 2t\vec j $.
The latter parameterization seems to be the same as mine, but it results in a different final answer. The question tells us to use the formula $$\int_{C_1}\vec F\ \cdot d\vec r= \int_a^b\vec F(\vec r(t)) \cdot \vec r'(t)dt$$ and using that formula with my parameterization results in a different answer than using it with the textbook's parameterization.
Why do two different but equivalent parameterizations of the curve result in different values for the line integral? And how do I know which parameterization to use/which the question is asking for?

Because your parameterisation describes a path which begins at $2\vec j$ and ends at $\vec i$, whereas it should begin at $\vec i$ and end at $2\vec j$ (as the other one does).