Let $X$ be a non-empty set of 4 points in the plane, and $(X,\mathrm{d})$ the euclidean metric on $X$. Let $(x_0,y_0)\in X^2$ be any pair of points in $X$ and $\overline{x_0y_0}$ a straight line joining them. Can we tell if the line $\overline{x_1y_1}$ between the remaining points will intersect $\overline{x_0y_0}$ using only points in $X$ and distances in the metric space? (Angles too, but no line extending is allowed).
I've been doing a lot of thinking, but the only logical conclussion i came up with is that this is impossible: to know if two line segments do not intersect each other i would need to prove they are either parallel or the intersection point lies outside the convex hull of $X$, but these are all properties of lines in the plane, not points in $X$.
You can indeed determine this just from the distances.
To see this, note that after applying an isometry of the plane, we can assume with no loss of generality that $x_0=(0,0)$, $y_0=(0,d)$ for some $d>0$, and $x_1$ lies in the (closed) upper half plane. Then $x_1$ is uniquely determined by its distance to $x_0$ and $y_0$, and similarly $y_1$ is uniquely determined by its distance to $x_0$ and $y_0$, up to a reflection across the horizontal axis.
But then from the two possible choices, $y_1$ is uniquely determined by its distance from $x_1$, except in the special case that both possible locations are equidistant from $x_1$, in which case $x_1$ must lie on the horizontal axis. In this latter case, reflection across the horizontal axis gives an isometry preserving $x_0$, $y_0$, and $x_1$, so we may assume that $y_1$ is in the upper half plane as well, and is still uniquely determined.
Since all four points have uniquely determined locations in the plane up to a planar isometry, one can determine the intersection (or lack thereof) using planar geometry.
Remark
The number $4$ isn't really important in this problem. That is, if we have any subset $X\subseteq \mathbb R^2$, then either:
or
The upshot is that any isometry between two planar subsets $X_1$ and $X_2$ extends to a linear isometry of the plane itself. As a corollary, any property of a planar subset $X$ that is invariant under planar isometries will be determined solely by the inherited metric on $X$. (A similar statement is also true in higher dimensions as well.)