Let $X$ be an arithmetic surface over $\mathbb Z$ with smooth generic fibre (which is a curve over $\mathbb Q$). Moreover assume that $X$ is given by one equation $F=0$.
added later: In other words, the generic fibre is expressed as a plane curve over $\mathbb Q$.
Now let $x\in X$ be a closed point. How do I check if $X$ is regular at $X$? Ok, formally I must show that $\mathcal O_{X,x}$ is a regular local ring (of Krull dimension 2). But in more concrete terms what should I do with my $F$? I mean, if $X$ was a variety over a field, I could use the Jacobian criterion, but what about this particular case where the base is $\operatorname{Spec} \mathbb Z$?
Remark: With the term arithmetic surface I mean an integral projective scheme of dimension $2$ which is flat over $\mathbb Z$.
Regularity is a local notion so we can work in affine coordinates $x,y$. The scheme $X$ is automatically regular at every point at which $X/\operatorname{Spec}\mathbb Z$ is smooth by the regularity of $\operatorname{Spec}\mathbb Z$. These are precisely the points satisfying the Jacobian criterion. Now, take a closed point $z$ of $X$ at which $X/\mathbb Z$ is not smooth, you have to show that $X$ is regular at $z$. Since the Krull dimension of $X$ at $z$ is $2$, this is equivalent to saying that the maximal ideal $\mathfrak m$ of $z$ in $\mathcal O_{X,z}$ can be generated by two elements. It is hard to say more without knowing what $F$ you are dealing with. By the answer to this question https://mathoverflow.net/questions/97429/maximal-ideals-of-zx-y you can always write $\mathfrak m=(p,f,g)$ where $p$ is a prime number, $f$ is a polynomial in $x$ irreducible mod $p$, and $g$ is a polynomial in $(x,y)$ irreducible mod $p$; and you could for example try to see if, modulo $F$, one of these three generators is in the ideal spanned by the other two.
As an illustrative example, take $F=xy-n$ for some integer $n\in \mathbb N$. A point $z\in X$ at which $X/\mathbb Z$ is not smooth corresponds to a maximal ideal $\mathfrak m$ of $\mathbb Z[x,y]/(F)$ of the form $(x,y,p)$ where $p$ is a prime dividing $n$. Then, $X$ is regular at $z$ if and only if $\mathfrak m$ is generated by two elements, i.e. if and only if $p^2$ does not divide $n$. In that case, $\mathfrak m$ is spanned by $x$ and $y$.