Let $U$ a universe and there are $n$ properties defined on it: $a_1,a_2,\dots,a_n$. Define the sum of the size of all $m$-intersection(s) of $A_i=\{x\in U|x\textrm{ has property }a_i\}$ to be: $S_m=\sum_{|I|=m}\left|\bigcap_{i\in I}A_i\right|$.
Now let $L_m$ counts the number of elements have at least $m$ properties, then
$$L_m=S_m-{m\choose m-1}S_{m+1}+{m+1\choose m-1}S_{m+2}-\dots+(-1)^{n-m}{n-1\choose m-1}S_n.$$
Is there any combinatorial way to explain the meaning of these coefficients?
The strange thing is that: Let $E_m$ counts the number of elements have exactly $m$ properties, then
$$E_m=S_m-{m+1\choose m}S_{m+1}+{m+2\choose m}S_{m+2}-\dots+(-1)^{n-m}{n\choose m}S_n,$$
and we can obtain $L_m$ by modifying $E_m$: for each coefficient $j\choose k$ of $E_m$, the corresponding one is $j-1\choose k-1$ for $L_m$.
This observation seems related to the shift by one property pointed out in a very great answer [https://math.stackexchange.com/a/809201/390226] by Mr. @Markus Scheuer:
$$E(z)=L(z-1)$$
which $E(z)$ and $L(z)$ are two generating functions
\begin{align*} L(z) = \sum_{k=0}^{n}l_kz^k\qquad\qquad E(z)=\sum_{k=0}^{n}e_kz^k \end{align*}
(Notice that $e_k$ is correspond to my $E_m$, and $l_k$ to $S_m$ in my question above.)

This is a rather pragmatic, semi-combinatorial answer. Nevertheless it might be useful for some more creative combinatorialists. We provide an interpretation of the binomial coefficients of $E_m$ and derive from them an interpretation of the binomial coefficients of $L_m$.
At first I'd like to introduce a slightly different notation.
Interpretation of binomial coefficients of $E_{=m}$:
We can now generalise:
Interpretation of binomial coefficients of $L_{\geq m}$:
Note: In order to see some more aspects regarding $\binom{j}{m}$, the coefficient of $S_j$ in $E_m$, we give here a proof of (1) following (2.39) in Richard P. Stanleys Enumerative Combinatorics, Vol. 1, Ed.02.
We obtain \begin{align*} \color{blue}{\sum_{j=m}^n}&\color{blue}{(-1)^{j-m}\binom{j}{m}S_j}\\ &=\sum_{j=m}^n(-1)^{j-m}\binom{j}{m}\sum_{{Q\subseteq P}\atop{|Q|=j}}L_{\geq} (Q)\\ &=\sum_{j=m}^n(-1)^{j-m}\binom{j}{m}\sum_{{Q\subseteq R\subseteq P}\atop{|Q|=j}}E_{=}(R)\\ &=\sum_{R\subseteq P}E_{=}(R)\sum_{Q \subseteq R}(-1)^{|Q|-m}\binom{|Q|}{m}\\ &=\sum_{R\subseteq P}E_{=}(R)\sum_{j=0}^{|R|}(-1)^{j-m}\binom{|R|}{j}\binom{j}{m}\\ &=\sum_{R\subseteq P}E_{=}(R)\binom{|R|}{m}\sum_{j=0}^{|R|}(-1)^{j-m}\binom{|R|-m}{|R|-j}\\ &=\sum_{R\subseteq P}E_{=}(R)\binom{|R|}{m}\delta_{|R|,m}\\ &\,\,\color{blue}{=E_{=m}} \end{align*} showing the validity of (1).