If I change coordinates from $(x,t)$ to $(u,v)$ via the formulas $u=x-ct$ and $v=x+ct$ then I want to show that $$\frac{\partial}{\partial x} - \frac{1}{c}\frac{\partial}{\partial t}=2\frac{\partial}{\partial u}$$ $$\frac{\partial}{\partial x}+\frac{1}{c}\frac{\partial}{\partial x}=2\frac{\partial}{\partial v}$$
but I'm not sure how to do this.
From $u = x-ct$ and $v = x+ct$ we get $$ x = \frac 12 (u+v), \quad t = \frac 1{2c} (v-u). $$ Hence, by the chain rule $$ \def\pd#1#2{\frac{\partial #1}{\partial #2}}\def\p#1{\pd{}#1}\p u = \pd xu \p x + \pd tu \p t = \frac 12 \p x - \frac 1{2c} \p t $$ and $$ \p v = \pd xv \p x + \pd tv \p t = \frac 12 \p x + \frac 1{2c} \p t. $$