Reviewing old homework sets for a class and I came across this integral:
$$\displaystyle \int_0^1 \int_0^{1-y} \cos\Big( \frac{x-y}{x+y} \Big) \; dx dy,$$
which the question suggests to evaluate using a change of coordinates; however, I haven't a clue where to begin to identify a useful change of coordinates.
I tried $u = x-y$ and $v = x+y$, but then wasn't sure how I'd convert the domain of integration.
After that, I looked to the given limits for inspiration and noticed that $0<x<1-y$ could be rewritten $y < x+y < 1$, so tried $u = x+y$ and $v = y$, which yielded
$$\displaystyle \int_0^1 \int_y^{1} \cos\Big( \frac{ u - 2y }{u} \Big) \; du\,dy,$$
but that doesn't seem any simpler than the original, to me.
Any advice would be appreciated!

Your original substitution was right. The original domain of integration is the triangle bounded by $x=0$, $y=0$, and $x+y=1$.
Since $x = \frac12(u+v)$, $y=\frac12(v-u)$, and $x+y=v$, these boundary curves correspond to the curves $v=-u$, $v=u$, and $v=1$ in the $uv$-plane.
Can you finish now? (You need to stop to consider whether you prefer to integrate $du\,dv$ or $dv\,du$.)