I want to construct independent non-negative random variables $X_1,X_2,X_3$ and $X_4$ such that $\mathbb{E}(X_n)=n$ and then maximize the probability: $$\mathbb{P}\left(X_1+X_2+X_3+X_4 \geq 11\right)$$
By Markov's inequality this must be smaller or equal to 10/11 but I would not know how to actually maximize this.
Thanks to Axolotl's comment, we see this is related to Feige's Conjecture. In Feige's Paper he references a much older conjecture (Conjecture 2) due to Samuels that would answer your problem. It says
Fortunately, he also claims that Samuels has proven this for $n\le 4$ in these two papers. So it appears this you can get the answer for finding the best value of $i$ above, though the proof might take a bit to work through.