Suppose $z_1, z_2$ be any two fixed points in the complex plane and let $\lambda_1, \lambda_2$ be two real numbers such that $\lambda_1+\lambda_2=1.$ If $a$ be the complex number such that $a=\lambda_1z_1+\lambda_2z_2,$ then we know that $z_1, z_2$ and $a$ are collinear. My question is
If $\lambda_1, \lambda_2$ be two complex numbers such that $\lambda_1+\lambda_2=1,$
What can we say about the position of complex number $a$ given by $a=\lambda_1z_1+\lambda_2z_2$ ?
I think there should be a relationship between $z_1, z_2$ and the locus of $a.$
Have you any idea? Thank you.

Let me restate your setting more clearly.
This is true and easy to prove: since $\lambda_2=1-\lambda_1$, we can rewrite the relation as $$ a-z_2=\lambda_1(z_1-z_2) $$ so the numbers of the form $a-z_2$ lie on the one dimensional real subspace of $\mathbb{C}$ generated by $z_1-z_2\ne0$.
In the case where $\lambda_1$ and $\lambda_2$ are allowed to be complex, the same holds, but now the points of the form $a-z_2=\lambda_1(z_1-z_2)$ describe the one dimensional complex subspace of $\mathbb{C}$ generated by $z_1-z_2$, which is the whole of $\mathbb{C}$.