Given a $58 \times 58$ block matrix : $\mspace{20mu}A=\begin{bmatrix} 0 & 0 & R\\ 0 & Q & T\\ P & S & U \end{bmatrix} \in \mathbb{R}^{58\times 58} $,
$P\in \mathbb{R}^{11\times 11}\mspace{10mu},\mspace{10mu}Q\in \mathbb{R}^{28\times 28}\mspace{10mu},\mspace{10mu}R\in \mathbb{R}^{19\times 19},$
$\det(P)=p \mspace{10mu},\mspace{10mu}\det(Q)=q \mspace{10mu},\mspace{10mu}\det(r)=r \\ \\ \det(A)=??$
I have no idea how to find the determinant.
First note that your matrix can be expressed as a permutation of an upper-triangular block matrix.
$$ A = \Pi A' = \begin{bmatrix} 0 & 0 & I_{19}\\ 0 & I_{28} & 0\\ I_{11} & 0 & 0 \end{bmatrix} \begin{bmatrix} P & S & U \\ 0 & Q & T \\ 0 & 0 & R \end{bmatrix} = \begin{bmatrix} 0 & 0 & R\\ 0 & Q & T\\ P & S & U \end{bmatrix}. $$
Now use the following facts:
This yields $$ det(A)=det(\Pi)det(A')=-pqr. $$