For the first difficulty, let $E^r$ be the rth page of a first quadrant spectral sequence with elements $E^r_{p,q}$ , where $p$ is the filtering degree.
Difficulty 1: On bullet 7 of Mosher and Tangora of page 76, he makes the following assertion - No element of $E^r_{n,0}$ can be a boundary. I don't understand why the boundary map $d^1_{n+1,0}:E^1_{n+1,0} \to E^1_{n,0}$ needs to be 0. If it isn't 0 then elements of $E^0_{n,0}$ will be boundaries.
Specializing to when $E^r$ is the $rth$ page of the serre spectral sequence of a fibration $(E,p,B)$... Difficulty 2: Mosher and Tangora say that assertion implies that there is a well defined map from $E^r_{n,0} \to E^2_{n,0}$. I put this as a separate difficulty because I understand the assertion in difficulty 1 when $r\geq 1$ and hence when $r\geq 2$. What is this map?