Consider the selection game $G_1(\mathcal C,\mathcal C)$ where $\mathcal C$ is associated with a class of open covers. Considering various possibilities for $\mathcal C$, do uncountable spaces admit winning Markov (relying on only the round number and the most recent move of the opponent) strategies for the second player?
(The answer will be modulo separation axioms: of course, any indiscrete space of arbitrary cardinality only allows the trivial open cover, and thus the second player has a trivial winning Markov strategy.)
If $\mathcal C = \mathcal K$, the set of compact subsets, then the reals are an example of an uncountable space where the second player has a winning Markov strategy in the game $\mathsf G_1(\mathcal C, \mathcal C)$. In fact, any uncountable hemicompact space is such an example.
By the duality results of Clontz' Dual Selection Games, the game $\mathsf G_1(\Omega,\Omega)$ is dual to the game $\mathsf G_1(\mathcal F, \neg \Omega)$ where $\Omega$ is the collection of $\omega$-covers of a space (all nontrivial open covers that capture each finite set) and $\mathsf G_1(\mathcal F,\neg \Omega)$ is the game where the first player chooses finite sets $F_n$ and the second player chooses open sets $U_n$ so that $F_n \subseteq U_n$. The first player wins $\mathsf G_1(\mathcal F, \neg \Omega)$ if the second player produces an $\omega$-cover. This is similar to the finite-open game.
As a similar example as in Steven Clontz' answer, the right-ordered reals is an example of an uncountable $T_0$ space in which P1 has a predetermined winning strategy in $\mathsf G_1(\mathcal F, \neg \Omega)$: P1 can simply select $\{-n\}$ in the $n^{\mathrm{th}}$ inning. Hence, the second player has a winning Markov strategy in $\mathsf G_1(\Omega,\Omega)$.
However, like before, being $T_1$ guarantees countability.
Assume $X$ is $T_1$ and that P1 has a winning predetermined strategy in $\mathsf G_1(\mathcal F, \neg\Omega)$ (equivalently, that P2 has a winning Markov strategy in $\mathsf G_1(\Omega,\Omega)$). Then we can let $F_n$ be the choice P1 makes in the $n^{\mathrm{th}}$ inning according to their predetermined winning strategy. We will show that $X = \bigcup_{n\in\omega} F_n$. If there were some $x \not\in \bigcup_{n\in\omega} F_n$, then $X \setminus \{x\}$ would be a valid attack against the first player's strategy which contradicts the fact that it is winning. So $X$ is countable.