A coin is tossed $5$ times and $5$ heads are observed. What is the probability the coin is biased in favour of heads? Does this question even have any meaning without using a significance level?
Let's have a look at the usual Binomial test.
Let $X$ be the random variable: the number of heads out of $5$ tosses. Then $X \sim B(5,p).\ H_0: p = 0.5;\ H_1: p > 0.5.$
Suppose $H_0$ is true, that is, $X \sim B(5,0.5)$. Then $P( X \geq 5) = P(X=5) = 0.5^5 = 0.03125.$ This is the probability that the coin actually is fair, and we just happened to get $5$ heads in a row. My question is: is the probability that the coin is not biased in favour of heads equal to $0.03125$? Or like I said at the beginning, is this question meaningless?

Yes, this question makes sense. However, to answer it you need first a prior distribution for the probability of rolling heads (i.e. your initial suppositions on possible values of $p$ presented in form of probability distribution). Because you decide between $p = \frac{1}{2}$ and $p > \frac{1}{2}$ (no matter how much), I, personally, think that the following prior will be most natural in this case: $p$ equals to $\frac{1}{2}$ with probability $\frac{1}{2}$ and is uniformly distributed on $[\frac{1}{2};1]$ otherwise.
Now, you need to find the posterior probability the following way (using Bayes theorem):
$$P(p=\frac{1}{2}|\text{ 5 heads in 5 tosses}) = \frac{P(\text{ 5 heads in 5 tosses}|p=\frac{1}{2})P(p=\frac{1}{2})}{P(\text{ 5 heads in 5 tosses})}$$
Note, that $P(\text{ 5 heads in 5 tosses}|p=p_0) = p_0^5$ for any $p_0 \in [\frac{1}{2}; 1]$ and thus for our prior we have:
$$P(\text{ 5 heads in 5 tosses}) = \frac{1}{2}(P(\text{ 5 heads in 5 tosses}|p=\frac{1}{2}) + \int_{\frac{1}{2}}^{1} P(\text{ 5 heads in 5 tosses}|p=t)dt) = \frac{1}{2}(\frac{1}{32} + \int_{\frac{1}{2}}^{1} t^5 dt) = \frac{1}{64} + \frac{1}{12}(1 - \frac{1}{64}) = \frac{25}{256}$$
Thus the posterior probability of the coin being unbiased is $$P(p=\frac{1}{2}|\text{ 5 heads in 5 tosses}) = \frac{\frac{1}{64}}{\frac{25}{256}} = \frac{4}{25}$$
And from that we can conclude, that the posterior probability of the coin being biased towards heads is:
$$P(p>\frac{1}{2}|\text{ 5 heads in 5 tosses}) = 1 - P(p=\frac{1}{2}|\text{ 5 heads in 5 tosses}) = \frac{21}{25}$$
Note, that you can get a different result from different prior (but the procedure of obtaining it will still be the same).