$$\int\frac{x^3}{\sqrt{81x^2-16}}dx$$ I started off doing $$u =9x$$ to get $$\int\frac{\frac{u}{9}^3}{\sqrt{u^2-16}}dx$$ which allows for the trig substitution of $$x = a\sec\theta$$
making the denomonator $$\sqrt{16\sec^2\theta-16}$$ $$\tan^2\theta + 1 = \sec^2\theta$$ $$\Rightarrow4\tan\theta$$ to give $$\int\frac{\frac{4\sec}{9}^3}{4\tan\theta}dx$$
Am I doing this correctly?
If Trigonometric Substitution is not mandatory,
make the following substitution $$\sqrt{81x^2-16}=u$$
$$\implies81x^2-16=u^2\implies162x\ dx=2u\ du\iff x\ dx=\frac{u\ du}{81}$$
and $x^2=\dfrac{u^2+16}{81}$
Hope you can take it from here