I'm trying to evaluate this sum:
$$ \sum\limits_{s = 0}^{500} (-1)^s \binom{3000 - 2s}{2000} \binom{2001}{s}$$
As I think we need to use an expansion of $(1 -x)^n (1+x)^k$, but I've tried several times, using different powers but stuck every time.
Could you help me, please?
Note: Please note, this is essentially the same as Marko Riedels answer. Here we simply avoid the integral notation which might be somewhat more convenient.
We obtain OPs expression by setting $n=1000$. We need one additional small step before we start calculating $S_n$.
Since $\binom{m}{k}=\binom{m}{m-k}$ and $\binom{-m}{k}=\binom{m+k-1}{k}(-1)^k$ the following is valid \begin{align*} \binom{3n-2s}{2n}=\binom{3n-2s}{n-2s}=\binom{-(2n+1)}{n-2s}(-1)^n \end{align*}
Observe the nice symmetry regarding $2n+1$. This will help simplifying $S_n$.
Comment:
In (1) we write the binomial coefficients as coefficients of polynomials (resp. series) $\binom{m}{k}=[x^k](1+x)^m$. Note, that the factor $(-1)^s$ is respected in $[y^s](1-y)^{2n+1}$.
In (2) we see that the representation as coefficients of polynomials is convenient, since we can put parts of the expression, which do not depend on $s$ outside the sum. We also use the rule $$[x^{n+m}]p(x)=[x^n]x^{-m}p(x)$$
In (3) we use the substitution rule (see also (1)): \begin{align*} (1-x^2)^{2n+1}&=\sum_{s\geq 0}\binom{2n+1}{s}(-1)^sx^{2s}\\ &=\sum_{s\geq 0}x^{2s}[y^s](1-y)^{2n+1} \end{align*}
In (4) we use the symmetry regarding $2n+1$ which helps cancelling a factor of $(1-x^2)^{2n+1}=(1-x)^{2n+1}(1+x)^{2n+1}$