Find all differentiable functions $f:R \to R$ that have property that
$$ f'\left(\frac{y+z}2\right) = \frac{f(y)-f(z)}{y-z}$$ for all $y \neq z $
I have not been able to get any strong result. The only necessary condition I have managed to get is $f(x) = f(-x) + 2xf'(0)$. But, clearly this is not sufficient as $f(x)= x^4$ is a counter-example. In a more general form we can write it as $f(c+x)=f(c-x)+ 2xf'(c)$ by putting $y=c+x$ and $z= c-x$.
Consider the last equation you wrote. By differentiating with respect to $x$, we have $$ f'(c+x) = -f'(c-x) + 2f'(c) $$ and differentiating with respect to $c$ gives $$ f'(c+x) = f'(c-x) + 2xf''(c). $$ If we put $c=x$ and subtract the two equations, we have $$ f'(x)-xf''(x) = f'(0) $$ for all $x\in \mathbb{R}$. Now consider the function $$ g(x) = \frac{f'(x)}{x} $$ for $x\neq 0$ and we can show that $g'(x) = -f'(0)/x^{2}$, so $f'(x) = f'(0) + Ax$ and $f(x) = B + f'(0)x + \frac{1}{2}Ax^{2}$ for some $A, B\in \mathbb{R}$. Hence $f$ is a polynomial with degree at most $2$ and you may found the constants $A$ and $B$.