Let,$4^{27}+4^{1000}+4^{x}=n^2$
$4^{2}(4^{25}+4^{998}+4^{x-2})=n^2$
LHS is multiple of 4.$n$ is also multiple of 4
Let $n=4a _1$.
$4^{2}(4^{25}+4^{998}+4^{x-2})=16.a_1^2$
$4^{25}+4^{998}+4^{x-2}=4.a_1^2$
It implies $4^{x-2}$ is also multiple of 4 . Therefore $x-4$ Is natural number.
$4^2(4^{23}+4^{994}+4^{x-4})=4.a_1^2$
$4^{23}+4^{996}+4^{x-4}=a_1^2$
LHS is multiple of 4.$a_1$ is also multiple of 4
Let $a_1=4a _2$.
Similarly , we can find infinitely many integers $a_1\gt a_2\gt a_3\gt ...\gt a_n$ that satisfies this equation. By using infinite decent we prove it has no solution.
It is fake proof. We can find natural number $n=1972$ such that $4^{27}+4^{1000}+4^{1972}$ is a perfect square.
Did you find which step is wrong?
We can write the expression as $4^{27}(1+4^{973}+4^{x-27})$, assuming $x>27$. Then $4^{x-27} = (2^{x-27})^2$ and the next biggest square is $(2^{x-27}+1)^2 = 4^{x-27}+2^{x-26}+1.$
Certainly $4^{27}$ is a square. In order for $1+4^{973}+4^{x-27}$ to be a square, it must be larger than or equal to $4^{x-27}+2^{x-26}+1.$ So we have
$$2^{x-27} +1 \leq 4^{973} + 1$$
which gives us $x\leq 1972$.
So we know there are only finitely many solutions.
Similarly, $4^{973}= (2^{973})^2$ and the next biggest square is $(2^{973}+1)^2 = 4{973}+2^{974}+1$, so we must have
$$4{973}+2^{974}+1 \leq 4^{973}+4^{x-27}+1$$
if the latter is to be a square. This inequality gives $x\geq 469.$
So now we "just" have to check every value from $x=496$ to $1972.$
We'll leave that for interested scholar...
Edit: I ran a quit Maple loop and found $x=514$ and $x=1972$ as the only solutions.