It concerns me that nothing is actually impossible in gambling. Even a one in a billion possibility is not impossible. So it makes me wonder how one could analyse data and say that something is so unlikely that there may be an issue with whatever produced the data.
How unlikely does something have to be before it can be said that it shouldn't have happened?
I'm guessing it would need to be a series of unlikely events in quick succession?
I'm far from an expert on statistics but I would like to learn more, have been studying variance, standard deviation and probability with a statistician recently, but many years to go before I can answer this myself.
This is answered by hypothesis testing and is a branch called statistical inference. Hypothesis testing answers exactly this kind of questions.
In simple words: I observed the outcome of the game $n$ times (10 or 20 or whatever) and based on these outcomes, I can determine how likely it is that a fair game produced this sequence of outcomes.
The answer is always given with a margin for error. This margin comes from the fact that you highlight, that in fact anything is possible.