how to compare two infinite dimensional operators

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Perturbation theory is crucial in quantum mechanics. I was wondering how to compare two operators in the case of two infinite-dimensional operator? Assume we have Hamiltonian $H_0$ and $V$. How formally I can show that $V \ll H_0$, such that I would expand in powers of $V$.

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Even on infinite-dimensional operator a norm may be definied, therefore reducing the problem to a one-dimensional one, where $|V| \ll |H_0|$ is a valid assumption

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Most likely, it is sufficient to show all the eigenvalues of $S = V H_0^{-1}$ have absolute value less than the spectral radius of whatever power series you have in mind.