I want to find a matrix $A \in \mathbb{C}^{2x4}$ and $b \in\mathbb{C}^{2}$ the solution of $Ax=b$ is: $$L = \left\{\pmatrix{1\\2\\0\\-1} + x_1\pmatrix{1\\-2\\2\\1} + x_2\pmatrix{2\\2\\-1\\1}\right\}$$
Therefore $\dim(A) = 4$, $\dim(\ker(A)) = 2$, $\dim(\operatorname{im}(A)) = 2$.
$A$ and $b$ have the following format:
$$ A= \begin{pmatrix} a_{11} & a_{12} & a_{13} & a_{14}\\ a_{21} & a_{22} & a_{23} & a_{24} \\ \end{pmatrix} b= \pmatrix{b_1\\b_2} $$
My idea is to solve the following equation for A and b:
$$A\,\pmatrix{1 + x_1 + 2x_2\\2 - 2x_1+ 2x_2\\2x_1 - x_2\\-1+x_1 + x_2} = b$$ Is this the right way to start? I get then a linear equation with 12 unknowns and only 2 equations. I know that there must be many solutions. Do I simply define some of them as 1 or 0?
If you do this you don't get a linear system with twelve unknowns and two equations. Firstly, computing the product of $A$ with a matrix with some entries unknown is not linear, because it will involve terms of the form $a_{ij}x_k$; and secondly, $x_1$ and $x_2$ are not unknowns, the equation has to hold for all values of $x_1$ and $x_2$.
You know that in general the set of solutions of a system $Ax=b$ is given (if non-empty) by $v_0+\operatorname{null}A$ for some solution $v_0$ (any one will do, but you need to know that there is at least one). Comparing this with the definition of $L$, you get that $A$ must be such that $$\operatorname{null} A=\operatorname{span} ((1,-2,2,1)^T , (2,2,-1,1)^T).$$ So you want the rows $A_1,A_2$ of $A$ to be linearly independent (so that $A$ has rank $2$) and such that $$A_i\cdot (1,-2,2,1)^T=0=A_i\cdot (2,2,-1,1)^T;$$ Taking the transpose of these equations shows that the rows of $A$ must form a basis of the space of solutions to the homogeneous linear system $$\left\{\begin{array}{lll}a_1-2a_2+2a_3+a_4 & = & 0 \\ 2a_1+2a_2-a_3+a_4 & = & 0 \end{array}\right.$$
Once you've found the matrix $A$, you need to make sure that $(1,2,0,-1)^T$ is a solution of the system $Ax=b$, so you just have to take $$b=A\cdot \pmatrix{1\\2\\0\\-1}.$$